Journal of Multiple Sclerosis and Neuroimmunology 12(2):43-46, 2021
Recurrent Hypertrophic Pachymeningitis Successfully Treated with Cyclophosphamide
Hyunjong Eom, MD, Min Kyung Kim, MD, Ji Hye Shin, MD, Ji Hyun Kim, MD, PhD
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
Hypertrophic pachymeningitis is a inflammatory disorder that causes fibrous thickening of the dura mater, presenting with headache, diplopia, focal deficit, and seizure. High-dose corticosteroid is generally accepted as the first-line treatment. Some cases were reported to be refractory to corticosteroid, and immunosuppressive drugs lead to clinicoradiologic resolution in such cases. Herein, we reported a patient with relapsing idiopathic hypertrophic pachymeningitis in whom neurological symptoms and radiological abnormalities were refractory to corticosteroids and were successfully reversed with cyclophosphamide treatment.
Journal of Multiple Sclerosis and Neuroimmunology 12(2):43-46, 2021
