Journal of Multiple Sclerosis and Neuroimmunology 12(2):60-63, 2021
A Case of Progressive Multifocal Leukoencephalopathy in Systemic Lupus Erythematosus While Titrating Mycophenolate Mofetil with Low-Dose Corticosteroid
Ilmo Kang, MD, Sanggon Lee, MD, MSc
Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea
Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease caused by the
reactivation of human polyomavirus JC in immunosuppressed patients. We report a systemic
lupus erythematosus (SLE) patient diagnosed with definite PML after titration of mycophenolate
mofetil based on characteristic MRI findings. After all, the patient eventually went through a fatal
clinical course. PML should be considered in the differential diagnosis if SLE patient presents
with new-onset focal neurological deficits, even during low-dose immunosuppressive therapy.
Journal of Multiple Sclerosis and Neuroimmunology 12(2):60-63, 2021
