Journal of Multiple Sclerosis and Neuroimmunology 11(1):21-24, 2020
Seronegative Neuromyelitis Optica Spectrum Disorder and Tuberculosis: A Case Report and Literature Review
Young Gi Min, MDa,b, Yoon-Ho Hong, MD, PhDb
Department of Neurology, Seoul National University Hospital, Seoul, Koreaa Department of Neurology, Seoul National University-Seoul Metropolitan Government Boramae Medical Center, Seoul, Koreab
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease
of the central nervous system that preferentially involves the optic nerve and spinal cord. We
report a patient who presented with acute transverse myelitis in the cervical spinal cord that
extended to the lower brainstem in whom active pulmonary tuberculosis (TB) was diagnosed
simultaneously. This report adds to the literature on the possible association between active TB
and seronegative NMOSD and highlights the need for special considerations in treating these
two conditions concurrently.
Journal of Multiple Sclerosis and Neuroimmunology 11(1):21-24, 2020
