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Journal of Multiple Sclerosis 8(2):24-30, 2017
New Diagnostic Criteria for Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
Soo Hyun Park, MD, Nam Hee Kim, MD, PhD
Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea
Precise differential diagnosis of neuromyelitis optica (NMO) and multiple sclerosis (MS) is critical because treatment and prognosis are distinct and disease modifying treatment of MS can aggravate NMO. The discovery of disease-specific aquaporin-4 antibody has facilitated differentiation of NMO from MS and recognition of a broader phenotypic spectrum referred to as neuromyelitis optica spectrum disorder (NMOSD). However, distinguishing NMOSD from MS remains challenging, as there is still an interface between seronegative NMOSD and MS. Diagnostic criteria have evolved to improve differentiation and early detection of MS and NMOSD. This review will focus on new guidelines for the diagnosis of patients who are suspected of having MS or NMOSD.

Journal of Multiple Sclerosis
8(2):24-30, 2017
KEY WORDS : Neuromyelitis optica, Neuromyelitis optica spectrum disorder, Multiple sclerosis, Magnetic resonance imaging, Diagnostic criteria