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Journal of Multiple Sclerosis 8(1):14-17, 2017
Neurosyphilis Manifesting as an Intramedullary Nodule with Rim Enhancement
Minkyeong Kim, MD, Sunhye Jung, MD, Jin-Hong Shin, MD, PhD
Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea
Neurosyphilis in spinal cord presenting as isolated gumma is extremely rare, which poses a clinical challenge since it is often mistaken for central nervous system tumor or parasite infection. With several serologic tests, magnetic resonance image (MRI) provides a diagnostic clue. Here in, we report a case with rapidly progressive weakness, whose spine MRI manifested isolated intramedullary gumma and extensive cord edema. Venereal disease research laboratory of cerebrospinal fluid was strongly reactive. Intravenous penicillin-G with high-dose steroid resulted in an excellent clinical improvement.

Journal of Multiple Sclerosis
8(1):14-17, 2017
KEY WORDS : Neurosyphilis, Spine MRI, Penicillin